Hepatitis C virus core protein-induced miR-93-5p up-regulation inhibits interferon signaling pathway by targeting IFNAR1

Figure 2 Serum miR-93-5p in patients with hepatitis C virus-1b infection is involved in pegylated interferon-α resistance. A: Receiver operating characteristics (ROC) curve shows an AUC value of 0.8846 for serum miR-93-5p concentration in distinguishing HCV-1b-infected patients from healthy subjects; B and C: ROC curve shows AUC values of 0.8562 and 0.9265 in distinguishing HCV-1b-infected patients with pegylated IFNα sensitivity or resistance from healthy subjects, respectively; D: ROC curve shows an AUC value of 0.8359 in distinguishing HCV-1b-infected patients with pegylated IFNα resistance from those with pegylated IFNα sensitivity. HCV: Hepatitis C virus; IFNα: Interferon-α.