β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice

Figure 1 Evaluation of lipopolysaccharide-induced liver injury in vivo . A and B: Serum levels of ALT and AST were detected using ELISA kits in β-arrestin 2 WT and β-arrestin 2 KO mice treated with LPS and vehicle; C: HE staining of liver tissue (magnification, × 200); D: Histology score of hemorrhage in β-arrestin 2 WT and KO mice treated with LPS and vehicle; E: TUNEL staining of liver tissue (magnification, × 200); F: Histology score of apoptosis in β-arrestin 2 WT and KO mice treated with LPS and vehicle; G: Immunohistochemical staining for MPO expression in liver tissues from β-arrestin 2 WT and β-arrestin 2 KO mice treated with LPS and vehicle, (magnification, × 200); H: MPO index in β-arrestin 2 WT and β-arrestin 2 KO mice treated with LPS and vehicle. ^aP < 0.05 vs vehicle control group; ^cP < 0.05 vs β-arrestin 2 WT mice. LPS: Lipopolysaccharide.