INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

Figure 6 Obeticholic acid (OCA) and INT-767 modulate ileal and hepatic FXR target gene expression to a similar degree after 2 wk of dosing in lean C57Bl/6 mice. A-D: Hepatic expression of BSEP, OST, CYP8b1, and SHP; E and F: Ileal mRNA expression of FGF-15 and SHP. ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 vs no treatment (dose = 0); ^cP < 0.05, ^dP < 0.01, ^fP < 0.001 vs corresponding INT-767 dose (two-way ANOVA with Bonferroni’s post-hoc test).