INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

Figure 3 INT-767 treatment for 8 wk reduces hepatic lipid deposition in ob/ob-NASH mice with biopsy-confirmed liver pathology. A: Liver lipid (HE staining); B: Fractional area of liver fat (HE staining); C: Processed (color coded) images to display hepatic lipid content. Lipid droplets (white), rejected structures (yellow), collagen (green), auto-fluorescence (blue); D: Fractional area of liver lipid area ratio (%), lipid droplet number (count in 15 mm² tissue area), and lipid droplet area (1 pixel = 0.39 μm, 2-PE analysis). ^bP < 0.001 (unpaired t-test).