Predictive and prognostic value of serum AFP level and its dynamic changes in advanced gastric cancer patients with elevated serum AFP

Table 6 Multiple Cox regression analysis of prognostic factors

Factor	HR	95%CI	P value
LM (present)	2.809	1.363-5.788	0.005a
PM (present)	4.243	2.026-8.883	< 0.001a
Non-regional LNM (present)	3.743	1.928-7.268	< 0.001a
Other hematogenous metastasis (present)	1.479	0.692-3.161	0.312
PVTT (present)	2.341	1.030-5.320	0.048a
Response (SD + PD)	1.92	0.953-3.867	0.068
AFP decline degree (< 50%)	1.876	0.980-3.589	0.057

^aP value < 0.05. LM: Liver metastasis; PM: Peritoneal metastasis; LNM: Lymph node metastasis; PVTT: Portal vein tumor thrombus; SD: Stable disease; PD: Progressive disease; HR: Hazard ratio.