Predictive and prognostic value of serum AFP level and its dynamic changes in advanced gastric cancer patients with elevated serum AFP

doi:10.3748/wjg.v24.i2.266

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2018; 24(2): 266-273
Published online Jan 14, 2018. doi: 10.3748/wjg.v24.i2.266

Table 4 Comparison of response, liver metastasis rate, and overall survival between alpha-fetoprotein ≥ 160 ng/mL and alpha-fetoprotein < 160 ng/mL groups n (%)

Variable	AFP ≥ 160 ng/mL	AFP < 160 ng/mL	P value
Overall ORR
PR	14 (30.4)	28 (68.3)	< 0.001^a
SD + PD	32 (69.6)	13 (31.7)
ORR to doublet regimens
PR	10 (26.3)	26 (70.3)	< 0.001^a
SD + PD	28 (73.7)	11 (30.7)
ORR to triplet regimens
PR	4 (57.1)	2 (50.0)	0.652
SD + PD	3 (42.9)	2 (50.0)
Liver metastasis rate	69.8%	50.0%	0.030^a
Median OS	13.0 mo	14.8 mo	0.712

^aP < 0.05. PR: Partial response; SD: Stable disease; PD: Progressive disease; ORR: Objective response rate; OS: Overall survival.

Citation: Wang YK, Shen L, Jiao X, Zhang XT. Predictive and prognostic value of serum AFP level and its dynamic changes in advanced gastric cancer patients with elevated serum AFP. World J Gastroenterol 2018; 24(2): 266-273
URL: https://www.wjgnet.com/1007-9327/full/v24/i2/266.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i2.266