Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

Table 3 Allele and genotype frequencies of IRF5 rs77416878C/T and rs2280714T/C in Vietnamese patients with hepatitis B virus-related liver diseases n (%)

IRF5 variants	HC,n = 242	CHB,n = 99	LC,n = 131	HCC,n = 149
rs77416878
CC	192 (79.4)	79 (79.8)	98 (74.8)	115 (77.2)
CT	48 (19.8)	19 (19.2)	32 (24.4)	31 (20.8)
TT	2 (0.8)	1 (1)	1 (0.8)	3 (2)
Allele
C	432 (89.3)	177 (89.4)	228 (87)	261 (87.6)
T	52 (10.7)	21 (10.6)	34 (13)	37 (12.4)
Dominant
CC	192 (79.4)	79 (79.8)	98 (74.8)	115 (77.2)
CT + TT	50 (20.6)	20 (20.2)	33 (24.4)	34 (22.8)
Recessive
CC + CT	240 (99.2)	98 (99)	130 (99.2)	146 (98)
TT	2 (0.8)	1 (1)	1 (0.8)	3 (2)
rs2280714
TT	84 (34.7)	31 (31.3)	47 (35.9)	39 (26.2)
TC	114 (47.1)	52 (52.5)	69 (52.7)	87 (58.4)
CC	44 (18.2)	16 (16.2)	15 (11.4)	23 (15.4)
Allele
T	282 (58.3)	114 (57.6)	163 (62.2)	165 (55.4)
C	202 (41.7)	84 (42.4)	99 (37.8)	133 (44.6)
Dominant
TT	84 (34.7)	31 (31.3)	47 (35.9)	39 (26.2)
TC + TT	158 (65.3)	78 (68.7)	84 (64.1)	110 (73.8)
Recessive
TT + TC	198 (81.8)	83 (83.8)	116 (88.6)	126 (84.6)
CC	44 (18.2)	16 (16.2)	15 (11.4)	23 (15.4)

HC: Healthy controls; CHB: Chronic hepatitis B; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma. All comparisons between groups using binary logistic model adjusted for age and gen did not indicate a significant difference (adjusted P > 0.05, data not shown in this table).