Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

Table 1 Clinical profiles of 242 healthy individuals and 379 hepatitis B virus-infected patients

Characteristics	HC (n = 242)	CHB (n = 99)	LC (n = 131)	HCC (n = 149)	P values
Age (yr)	39 (18-79)	41 (19-78)	52 (17-78)	53 (18-79)	< 0.0001
Gender (Male/Female)	156/86	82/17	105/26	119/30	< 0.0001
AST (IU/L)	NR	219 (17-3732)	74 (12-720)	59 (16-513)	< 0.0001
ALT (IU/L)	NR	158 (12-4593)	59 (9-1354)	47 (13-471)	< 0.0001
Total bilirubin (µmol/L)	NR	46.6 (1.8-795)	31 (1.2-722)	17 (2-290)	< 0.0001
Direct bilirubin (µmol/L)	NR	29.9 (1-512)	17 (1-450)	7.1 (1.2-189)	< 0.0001
Albumin (g/L)	NR	42 (23-48)	30 (20-47)	39 (27-49)	< 0.0001
Prothrombin (% of standard)	NR	85 (50-120)	47.5 (15-101)	80 (31-115)	< 0.0001
HBV-DNA (copies/mL)	NA	1.8 × 105 (4 × 102-8.1 × 106)	8.3 × 104 (2 × 102-4.1 × 106)	9.4 × 104 (2.9 × 102-1.0 × 105)	NS
Alfa Feto Protein (IU/L)	NR	4.3 (1.5-300)	8.6 (1.2-400)	196 (1.1- 438)	< 0.0001

CHB: Chronic hepatitis B; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; PLT: Platelets; AST and ALT: Aspartate and alanine amino transferase; IU: International unit; NS: Not significant; NA: Not applicable. NR: Normal range.