Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

Figure 5 Representation by sequence logos of the information content of the conserved region in the the core and X protein amino acid sequence (aa 63-76). The relative sizes of the letters in each stack in the sequence logos indicate their relative frequencies at each position within the multiple alignments of aa haplotypes obtained. The total height of each stack of letters depicts the IC of each aa position, measured in bits (Y-axis): 0 bits being the minimum and 4.32 bits the maximum conservation. Amino acids belonging to the Kunitz-like domain portion are framed in green. IC: Information content.