Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

Table 1 Main clinical and virological characteristics of the hepatitis B virus infected patients enrolled

Patient	Age	Sex	Origin	Clinical stage	HBeAg	HBV DNA(log IU/mL)	ALT (IU/L)	Genotype1
1	27	M	Sub-Saharan	Chronic hepatitis	Negative	7.8	170	E
2	31	M	Asian	Chronic hepatitis	Negative	6.6	103	C
3	51	M	Caucasian	Chronic hepatitis	Negative	6.6	262	D
4	28	F	Caucasian	Chronic hepatitis	Negative	7.9	126	D
5	47	F	Caucasian	Chronic hepatitis	Negative	6.3	170	D
6	37	F	Caucasian	Chronic hepatitis	Negative	4.5	53	D
7	37	M	Caucasian	Chronic hepatitis	Negative	4.5	33	F
8	38	M	Caucasian	Chronic hepatitis	Negative	5.0	29	D
9	46	M	Caucasian	Chronic hepatitis	Negative	5.8	88	F
10	46	F	Caucasian	Chronic hepatitis	Negative	5.3	23	H
11	71	F	Caucasian	Chronic hepatitis	Negative	6.2	87	F
12	51	M	Asian	Chronic hepatitis	Negative	5.7	435	C
13	52	M	Caucasian	Chronic infection	Negative	4.4	18	A
14	40	F	Caucasian	Chronic infection	Negative	4.2	29	D
15	33	M	Asian	Chronic infection	Negative	4.3	25	D
16	63	M	Hispanic	Cirrhosis	Negative	4.0	16	A
17	53	M	Caucasian	Cirrhosis/HCC	Negative	3.7	36	A
18	35	M	Sub-Saharan	Chronic hepatitis	Positive	5.7	36	E
19	37	M	Caucasian	Chronic hepatitis	Positive	8.4	32	C
20	45	M	Caucasian	Chronic hepatitis	Positive	5.6	35	A
21	29	F	Asian	Chronic hepatitis	Positive	6.9	355	B
22	28	M	Asian	Chronic hepatitis	Positive	> 8.0	341	C
23	28	M	Asian	Chronic infection	Positive	8.7	24	C
24	28	F	Asian	Chronic infection	Positive	8.8	22	C
25	55	F	Caucasian	Cirrhosis	Positive	5.4	73.9	A
26	82	F	Caucasian	Cirrhosis/HCC	Positive	4.8	24	C
27	64	M	Caucasian	Cirrhosis/HCC	Positive	6.3	45	D

¹Genotype determined by Sanger sequencing of the X region (same region as was analyzed by next-generation sequencing). ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; M: Male; F: Female; HBV: Hepatitis B virus.