Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

Figure 1 Developmental process of hepatocellular carcinoma via nonalcoholic steatohepatitis. Based on excessive lipids accumulation, several factors such as inflammatory cytokines, oxidative stress or proliferating pathways are involved in the whole process of hepatocellular carcinoma development from nonalcoholic steatohepatitis status via nonalcoholic fatty liver disease. NAFLD: Nonalcoholic fatty liver disease; HCC: Hepatocellular carcinoma; NASH: Nonalcoholic steatohepatitis.