Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease

Table 7 Significant associations between serum biomarkers and height z-scores [based on bone age (n = 49)] - unadjusted analyses

Variable	Height BA-z-scores	Point estimate1	95%CI	P value
Albumin	Males and females	0.8	0.22, 1.36	0.008
CRP	Males and females	-0.06	-0.11, -0.006	0.03
ESR	Males and females	-0.02	-0.05, -0.003	0.029
IGF-1 BA-z-scores	Males and females	0.26	0.03, 0.48	0.025

¹Regression coefficient for unadjusted analyses [i.e., one serum biomarker (independent variable) per model and no adjustment for potential confounding]. BA z-score: z score based on bone age; BMI: Body mass index; ESR: Erythrocyte sedimentation rate; IGF-1: Insulin-like growth factor-1; CRP: C-reactive protein.