Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease

Table 6 Significant associations between medications/serum biomarkers and height z-scores by sex (based on chronological age (female n = 35; male n = 47)) - unadjusted analyses

Variable	Height CA z-scores	Point estimate1	95%CI	P value
Infliximab	Females	0.65	0.04, 1.25	0.038
CRP	Males	-0.04	-0.079, -0.002	0.039
ESR	Males	-0.03	-0.051, -0.011	0.003
Hemoglobin	Males	0.23	0.04, 0.42	0.018
Platelets	Males	-0.004	-0.006, -0.001	0.005

¹Regression coefficient for unadjusted analyses [i.e., one medication or serum biomarker (independent variable) per model and no adjustment for potential confounding]. CA z-score: z score based on chronological age; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate.