Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease

Table 4 Significant associations between medications/serum biomarkers and anthropometric parameters [z-scores based on chronological age (n = 82)] - adjusted analyses

Variable	Mid-arm circumference CA-z-scores	Subscapular skinfold CA-z-scores	Weight CA-z-scores	BMI CA-z-scores
Adalimumab		1.021 (0.18, 1.86)2 0.0183		1.17 (0.13, 2.21) 0.029
Azathioprine	-0.64 (-1.26, -0.02) 0.045	-0.47 (-0.83, -0.10) 0.014	-0.73 (-1.17, -0.29) 0.002	-0.58 (-1.03, -0.12) 0.013
Methotrexate		0.81 (0.10, 1.53) 0.027
ESR			-0.03 (-0.05, -0.01) 0.01	-0.03 (-0.05, -0.004) 0.024

¹Regression coefficient for adjusted analyses [i.e., one medication or serum biomarker (independent variable) per model and CA at study visit, sex, CRP, albumin, ESR and hemoglobin are included in the model to adjust for potential confounding];

²(95% confidence interval);

³P-value. BMI: Body mass index; CA z-score: z score based on chronological age; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate.