Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease

Table 3 Significant associations between medications/serum biomarkers and anthropometric parameters [z-scores based on chronological age (n = 82)] - unadjusted analyses

Variable	Mid-arm circumference CA-z-scores	Subscapular skinfold CA-z-scores	Weight CA-z-scores	BMI CA-z-scores
Adalimumab		0.901 (0.08, 1.72)2 0.0333		1.09 (0.05, 2.13) 0.04
Azathioprine	-0.65 (-1.25, -0.05) 0.033	-0.5 (-0.85, -0.14) 0.006	-0.7 (-1.16, -0.23) 0.004	-0.56 (-1.004, -0.12) 0.014
Methotrexate		0.75 (0.06, 1.43) 0.032
ESR	-0.024 (-0.05, -0.002) 0.036		-0.03 (-0.05, -0.02) 0.0003	-0.02 (-0.04, -0.006) 0.009
Hemoglobin			0.19 (0.04, 0.34) 0.015

¹Regression coefficient for unadjusted analyses [i.e., one medication or serum biomarker (independent variable) per model and no adjustment for potential confounding];

²(95% confidence interval);

³P-value. BMI: Body mass index; CA z-score: z score based on chronological age; ESR: Erythrocyte sedimentation rate.