Copyright
©The Author(s) 2018.
World J Gastroenterol. May 7, 2018; 24(17): 1901-1910
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1901
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1901
Figure 2 BSO and NAC influence the α-hederin-induced apoptosis of SMMC-7721 cells.
SMMC-7721 cells were incubated with α-hederin (10 μmol/L) with or without BSO (2 mmol/L) or NAC (5 mmol/L) pretreatment. A: Cell apoptosis was determined by Hoechst 33258 staining; B: ROS levels in SMMC-7721 cells; C and D: Effect of α-hederin on intracellular GSH and ATP levels. aP < 0.05 vs control; cP < 0.05 vs α-hederin (10 μmol/L). ATP: adenosine triphosphate; BSO: DL-buthionine-S,R-sulfoximine; GSH: Glutathione; NAC: N-acetylcysteine.
- Citation: Li J, Wu DD, Zhang JX, Wang J, Ma JJ, Hu X, Dong WG. Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells. World J Gastroenterol 2018; 24(17): 1901-1910
- URL: https://www.wjgnet.com/1007-9327/full/v24/i17/1901.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i17.1901