Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models

Figure 2 Effect of plecanatide (A) and dolcanatide (B) on lipopolysaccharide-induced increased permeability of 4 kD fluorescein isothiocyanate-dextran across rat colon tissues. Rat colon tissues (2 cm pieces) were incubated overnight with vehicle, 10 μM plecanatide or dolcanatide in the presence or absence of 100 μg/mL LPS. Data represent mean fluorescence ± SEM recorded 75 min after the addition of FITC-dextran. D: Dolcanatide; FITC: Fluorescein isothiocyanate; LPS: Lipopolysaccharide; P: Plecanatide; RFU: Relative fluorescence units; SEM: Standard error of the mean.