Review
Copyright ©The Author(s) 2018.
World J Gastroenterol. May 7, 2018; 24(17): 1825-1838
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1825
Table 1 Summary of relevant NA treatment discontinuation studies
Patients off NA, n
Treatment characteristics
Outcomes
Study
Total
HBeAg(+)
HBeAg(-)
Cirrhosis
Age in year
Sex, male
Ethnicity
NA
Treatment duration in mo
Durable virologic response, n
HBsAg loss, nDeaths, n
Fung et al[100] (2004)2702774540AsianLMV2415NR0
Enomoto et al[101] (2008)2202234915AsianLMVNR5NR0
Yeh et al[102] (2009)71710114155AsianLMVNR5200
Fung et al[103] (2009)22220NR2816AsianLMV748NR0
Wang et al[104] (2010)1251250026/3295AsianLMV24-3687NR0
Kuo et al[105] (2010)1241240NRNRNRAsianLMV1442NR1
Cai et al[106] (2010)11110NR2912AsianTBV244NR0
Liu et al[40] (2011)6106103250AsianLMV273080
Jung et al[107] (2011)1910943712AsianADV331300
Chan et al[30] (2011)53053185643AsianLMV27169NR
Chaung et al[108] (2012)39390NR3424AsianLMV, ADV, ETV21400
Hadziyannis et al[29] (2012)3303305338CaucasianADV5618140
Ha et al[41] (2012)1450145NR33101AsianADV2650NR0
Song et al[109] (2012)4848004229AsianETV, CLE2628NRNR
He et al[110] (2013)6606603550AsianLMV, ADV, ETV, TBV374720
Kim et al[111] (2013)4504594533AsianLMV, ADV, ETV3812NRNR
Jeng et al[44] (2013)95095395283AsianETV244000
Kwon et al[112] (2013)16NRNRNRNRNRAsianLMV791220
Ridruejo et al[113] (2014)353320NRNRCaucasianETV422618NR
Sohn et al[114] (2014)954154444753AsianLMV, ETV, CLE221600
Patwardhan et al (2014)3303304224MixedLMV, ADV, ETV, TDF641200
He et al[115] (2014)97970NR2653AsianLMV, ADV, ETV, TBV3589110
Chen et al[31] (2014)188831051238/49143AsianLAM20-226323NR
Jiang et al[116] (2015)72333983653AsianLMV, LMV + ADV, ADV, ETV, TBV3325NR0
Seto et al[117] (2015)18401843454125AsianETV371500
Huang et al[118] (2003)32032NR4629AsianLMV914NRNR
Marcellin et al[119] (2004)18101815340156AsianLMV125300
Lai et al[120] (2006)1325/3130325/31316/3144/44248/236MixedETV/ LMV≥13124/781/122
Marcellin et al[121] (2009)3181/850181/8540/39156/74AsianLMV1252/330/012
Paik et al[122] (2010)50050153943AsianLMV2425NR0
Liang et al[123] (2011)84414303756AsianLMV, ADV, ETV or LMV +ADV33475NR
Jin et al[124] (2012)13810236173982AsianLMV35116820
Berg et al[32] (2017)2102104533CaucasianTDF≥ 481340
Van Hees et al[35] (2018)62620114345CaucasianLMV, TDF, ETV, LMV + ADV703262
Rivino et al[43] (2018)421/270/021/270/043/5114/19Caucasian/AsianTDF, LMV≥ 24/≥ 244/140/0NR