Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis

Figure 5 Inhibition of CRH-R2 signaling reduces epithelial cell proliferation in DSS-induced colitis. A-K: Representative images from Ki-67 immunoreactive sections; L: Quantification of Ki-67 immunohistochemistry data. Data presented as mean ± standard deviation, n = 6 per group, scale bar = 50 μm. ^cP < 0.05, ^dP < 0.01 vs control group; ^aP < 0.05, ^bP < 0.01 vs DSS group. ^fP < 0.01 vs Ucn2 group; ^eP < 0.05 vs TXYF-L group; ^gP < 0.01 vs TXYF-M group; ^hP < 0.01 vs TXYF-H group. CRH-R2: Corticotropin-releasing hormone-receptor 2; DSS: Dextran sulfate sodium; TXYF: Tong-Xie-Yao-Fang.