Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis

Figure 4 Inhibition of CRH-R2 signaling promotes colonic epithelial cell apoptosis in DSS-induced colitis. A-K: Representative images from TUNEL sections; L: Quantification of TUNEL data. Data are presented as mean ± standard deviation, n = 6 per group, scale bar = 50 μm. ^dP < 0.001 vs control group; ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs DSS group; ^eP < 0.001 vs Ucn2 group; ^gP < 0.01 vs TXYF-L group; ^hP < 0.01 vs TXYF-M group; ^fP < 0.001 vs TXYF-H group. CRH-R2: Corticotropin-releasing hormone-receptor 2; DSS: Dextran sulfate sodium; TUNEL: Terminal deoxynucleotidyl transferase dUTP nick-end labeling; TXYF: Tong-Xie-Yao-Fang.