Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis

Figure 1 Inhibition of CRH-R2 signaling aggravates symptoms of DSS-induced colitis in mice. A: Mice body weights measured for 16 d, and shown as percentage of weight change; B: Colon length; C: Representative photographs of colon lengths; D: DAI; E: Histological scores were evaluated on the 16^th day; F: Representative images of hematoxylin-eosin staining histology. Data are presented as mean ± standard deviation, n = 6-10 per group, scale bar = 200 μm. ^aP < 0.001 vs control group; ^gP < 0.05, ^bP < 0.001 vs DSS group; ^cP < 0.001 vs Ucn2 group; ^hP < 0.05 vs TXYF-L group; ^fP < 0.01, ^dP < 0.001 vs TXYF-M group; ⁱP < 0.05, ^eP < 0.001 vs TXYF-H group. CRH-R2: Corticotropin-releasing hormone-receptor 2; DAI: Disease activity index; DSS: Dextran sulfate sodium; TXYF: Tong-Xie-Yao-Fang.