Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

Figure 3 Histopathological grading of C57BL6J, ob/ob low-fat diet and ob/ob AMLN liver. Individual grades of steatosis (A), inflammation (B), biliary hyperplasia (C), CD68-positive cells (D) and ballooning degeneration (E) are shown; (F): Comparison of the total NASH scores representing the sum of all histologic parameters. ^bP ≤ 0.01, ^dP ≤ 0.0001 vs C57BL6J; ^fP ≤ 0.01, ^hP ≤ 0.0001 vs LFD. LFD: Low-fat diet.