Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

Figure 1 Obese ob/ob mice display increased hyperinsulinemia on AMLN diet. (A): Average body weight over 12-wk disease induction period; (B): Terminal non-fasting blood glucose levels; (C): Terminal non-fasting plasma insulin levels; (D): Pancreatic insulin content. ^aP ≤ 0.05, ^bP ≤ 0.01, ^dP ≤ 0.0001 vs C57BL6J. LFD: Low-fat diet.