Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

Table 3 Positive relationships between HBeAg negative serostatus and preexisting reverse transcriptase mutation frequency in the treatment- naïve patients

HBeAg-positive		HBeAg-negative		HBV genotype (%)	Location	Ref.
Mutations1	HBV-DNA2	Mutations1	HBV-DNA2
3/14 (21.4)	7.8	11/14 (78.6)	5.7	B, C, E	California	[26]
6/24 (25.0)	5.5	18/24 (75.0)	3.9	B, C, B-C	China	[27]
0/4 (0.0)	7.2	4/4 (100.0)	4.7	A, B, C, D, F	California	[45]
3/6 (50.0)	8.0	3/6 (50.0)	3.2	D	Turkey	[36]
8/12 (67.0)	7.9	4/12 (33.0)	6.9	NA	Taiwan, China	[35]
27/43 (62.8)	5.7	16/43 (37.2)	4.7	B, C	China	[46]
8/13 (61.5)	6.3	5/13 (38.5)	5.4	B, C	China	[47]
0/5 (0.0)	NA	5/5 (100.0)	NA	NA	Japan	[34]
0/4 (0.0)	NA	4/4 (100.0)	NA	NA	Japan	[88]

¹Number of patients with RT mutation (%);

²HBV-DNA level (log₁₀ IU/mL).