Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

Table 1 List of pathways involved in nonalcoholic fatty liver disease selected from significant Q-values that dependent on both genes and metabolites analyzed jointly

Pathway name	Q-joint
Solute carriers -mediated transmembrane transport	1.23E-12
Transmembrane transport of small molecules	9.66E-12
Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds	8.40E-10
Leukotriene biosynthesis	8.71E-10
Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds	1.91E-09
Transport of inorganic cations-anions and amino acids-oligopeptides	4.27E-09
Amino acid and oligopeptide SLC transporters	1.10E-08
Transport of inorganic cations/anions and amino acids/oligopeptides	2.40E-08
tRNA Aminoacylation	3.03E-08
Gamma-glutamyl cycle	3.61E-08
tRNA charging	5.96E-08
mRNA protein and metabolite induction pathway by cyclosporine A	8.47E-08
Class I MHC mediated antigen processing & presentation	1.73E-07
Na+/Cl- dependent neurotransmitter transporters	3.10E-07
Amino acid transport across the plasma membrane	3.72E-07
S-methyl-5-thio-alpha;-D-ribose 1-phosphate degradation	6.17E-07
Amine compound solute carrier transporters	6.17E-07
Protein digestion and absorption - homo sapiens (human)	2.13E-06
Amino acid interconversion	2.21E-06
Biochemical pathways part I	2.34E-06
Amino acid metabolism	3.96E-06
Aminoacyl-tRNA biosynthesis - homo sapiens (human)	6.88E-06
Metabolism of amino acids and derivatives	8.72E-06
Mineral absorption - homo sapiens (human)	1.47E-05
Cytosolic tRNA aminoacylation	2.86E-05
Mitochondrial tRNA aminoacylation	2.86E-05
tRNA Aminoacylation	2.86E-05
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	0.000159
Gene expression	0.000181
Tryptophan catabolism	0.000275
Phase II conjugation	0.000426
Phenylalanine and tyrosine catabolism	0.003
Glutamine and glutamate metabolism - homo sapiens (human)	0.00376
Glutaminolysis and cancer	0.00493
Glycine metabolism	0.0052
Glutamate glutamine metabolism	0.00665
Recycling of bile acids and salts	0.00669
Glycine serine alanine and threonine metabolism	0.0101
Branched-chain amino acid catabolism	0.0103

OMICs-integrative analysis was performed using the IMPaLA (integrated molecular pathway level analysis, http://impala.molgen.mpg.de)[67] platform. A joined adjusted P-value (Q-value) was calculated to control for multiple testing by false discovery rate.