Post-polypectomy bleeding and thromboembolism risks associated with warfarin vs direct oral anticoagulants

Table 2 Crude and adjusted odds ratios for post-polypectomy bleeding in controls (n = 218), anticoagulant users (n = 218), warfarin users (n = 145), and direct oral anticoagulants users (n = 73)

Subjects	Crude OR (95%CI)	P value	Propensity score-adjusted OR1 (95%CI)	P value
Controls	1 (referent)		1 (referent)
AC users	17.2 (4.1-73.1)	< 0.001	18.9 (4.2-85.5)	< 0.001
Warfarin users	17.3 (4.0-75.2)	< 0.001	18.6 (3.8-89.9)	< 0.001
DOAC users	17.1 (3.7-80.3)	< 0.001	17.8 (3.2-98.8)	0.001

¹Propensity score estimations. Values in parentheses are percentages. Values presented with a plus/minus sign are means ± SD; bold type indicates statistical significance (P < 0.05). AC users vs controls: Logistic regression model included 17 factors that are potentially clinically important variables; area under the receiver operating characteristic (ROC) curve for propensity scores for AC users was 0.81 (95%CI: 0.77-0.85); Warfarin users vs controls: Logistic regression model included 18 factors that are potentially clinically important variables; area under the ROC curve for propensity scores for warfarin users was 0.83 (95%CI: 0.78-0.88); DOAC users vs controls: Logistic regression model included 14 factors that are potentially clinically important variables; area under the ROC curve for DOAC user propensity scores was 0.85 (95%CI: 0.80-0.90). NA: Not applicable; AC: Anticoagulants; DOAC: Direct oral anticoagulants; HPB: Heparin bridge; OR: Odds ratio.