Hepatocellular carcinoma or interferon-based therapy history attenuates sofosbuvir/ribavirin for Japanese genotype 2 hepatitis C virus

Figure 5 Virological response in patients with sofosbuvir and ribavirin combination therapy categorized by single nucleotide polymorphisms related to anti-hepatitis C virus therapy, pretreatment viral status, ribavirin dose, and rapid virological response. A: IL28B single nucleotide polymorphisms rs8099917 (TT or non TT); B: ITPA single nucleotide polymorphisms rs1127354 (CC or non CC); C: Hepatitis C virus genotype (2A or 2B); D: Pretreatment viral load (< 6 logIU/mL or ≥ 6 logIU/mL); E: Ribavirin dose reduction (− or +); F: Rapid virological response (− or +). ^aP < 0.05: Significant difference. IL28B: Interleukin-28B; ITPA: Inosine triphosphate pyrophosphatase; RBV: Ribavirin; RVR: Rapid virological response.