Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

Table 6 Univariate and multivariate analysis of overall survival in gallbladder cancer patients according to the combination of fibrinogen and CA199

Characteristics	HR (95%CI)	Wald	P value
Univariate analysis
Combined fibrinogen and CA199	-		< 0.001
0
1
1.1
2.1
Multivariate analysis
Resection margin status	1.973 (1.289-3.020)		0.002
Negative
Positive
TNM stage	11.299		0.011
IIA-IIB stage/0-1 stage	1.342 (0.318-5.659)	0.160	0.689
IIIA-IIIB stage/0-1 stage	3.812 (1.158-12.545)	4.848	0.028
IVA-IVB stage/0-1 stage	5.189 (1.491-18.055)	6.699	0.010
Combined fibrinogen and CA199	14.218		0.003
1/0	1.784 (0.775-4.104)	1.854	0.173
1.1/0	1.895 (0.943-3.806)	3.222	0.073
2.1/0	3.195 (1.676-6.090)	12.454	0.000

The number 0 for fibrinogen concentration > 3.47g/L with CA199 level > 25.45 U/mL group, number 1 for fibrinogen concentration > 3.47 g/L with CA199 level ≤ 25.45 U/mL group, number 1.1 for fibrinogen concentration ≤ 3.47g/L with CA199 level > 25.45 U/mL group, and number 2.1 for fibrinogen concentration ≤ 3.47 g/L with CA199 level ≤ 25.45 U/mL group.