Daclatasvir plus asunaprevir in treatment-naïve patients with hepatitis C virus genotype 1b infection

Table 5 SVR12 in cirrhotic and noncirrhotic hepatitis C virus genotype-1b-infected patients with and without resistance-associated polymorphisms at baseline (placebo-deferred treatment arm) n (%)

	Patients with cirrhosis - placebo-deferred treatment arm
	With RAPs at baseline				Without RAPs at baseline
	Mainland China	Russia	South Korea	Overall	Mainland China	Russia	South Korea	Overall
Patients with cirrhosis
NS5A-L31M/V	0	0	0	0	3/5 (60.0)	1/1 (100)	1/1 (100)	5/7 (71.4)
Y93H	1/3 (33.3)	0	0	1/3 (33.3)	2/2 (100)	1/1 (100)	1/1 (100)	4/4 (100)
L31M/V or Y93H	1/3 (33.3)	0	0	1/3 (33.3)	2/2 (100)	1/1 (100)	1/1 (100)	4/4 (100)
NS3-D168E	0	0	0	0	3/5 (60.0)	1/1 (100)	1/1 (100)	5/7 (71.4)
Patients without cirrhosis
NS5A-L31M/V	0	0	0	0	30/36 (83.3)	5/5 (100)	2/2 (100)	37/43 (86.0)
Y93H	1/5 (20.0)	0	0	1/5 (20.0)	29/31 (93.5)	5/5 (100)	2/2 (100)	36/38 (94.7)
L31M/V or Y93H	1/5 (20.0)	0	0	1/5 (20.0)	29/31 (93.5)	5/5 (100)	2/2 (100)	36/38 (94.7)
NS3-D168E	0	0	0	0	30/36 (83.3)	5/5 (100)	2/2 (100)	37/43 (86.0)

RAP: Resistance-associated polymorphism; SVR12: Sustained virologic response at posttreatment week 12.