Daclatasvir plus asunaprevir in treatment-naïve patients with hepatitis C virus genotype 1b infection

doi:10.3748/wjg.v24.i12.1361

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2018; 24(12): 1361-1372
Published online Mar 28, 2018. doi: 10.3748/wjg.v24.i12.1361

Table 3 SVR12 in cirrhotic and non-cirrhotic hepatitis C virus genotype 1b-infected patients with and without resistance-associated polymorphisms at baseline (immediate treatment arm) n (%)

	Patients with cirrhosis - immediate treatment arm
	With RAPs at baseline				Without RAPs at baseline
	Mainland China	Russia	South Korea	Overall	Mainland China	Russia	South Korea	Overall
Patients with cirrhosis
NS5A-L31M/V	0	0	0	0	15/16 (93.8)	0	2/3 (66.7)	17/19 (89.5)
Y93H	0	0	0	0	15/16 (93.8)	0	2/3 (66.7)	17/19 (89.5)
L31M/V or Y93H	0	0	0	0	15/16 (93.8)	0	2/3 (66.7)	17/19 (89.5)
NS3-D168E	0	0	0	0	15/16 (93.8)	0	2/3 (66.7)	17/19 (89.5)
Patients without cirrhosis
NS5A-L31M/V	1/1 (100)	1/1 (100)	0	2/2 (100)	93/101 (92.1)	21/22 (95.5)	8/10 (80.0)	122/133 (91.7)
Y93H	7/13 (53.8)	0	0/2 (0)	7/15 (46.7)	87/89 (97.8)	22/23 (95.7)	8/8 (100)	117/120 (97.5)
L31M/V or Y93H	8/14 (57.1)	1/1 (100)	0/2 (0)	9/17 (52.9)	86/88 (97.7)	21/22 (95.5)	8/8 (100)	115/118 (97.5)
NS3-D168E	0/1 (0)	0	0	0/1 (0)	94/101 (93.1)	22/23 (95.7)	8/10 (80.0)	124/134 (92.5)

RAP: Resistance-associated polymorphism; SVR12: Sustained virologic response at posttreatment week 12.

Citation: Wei L, Wang FS, Zhang MX, Jia JD, Yakovlev AA, Xie W, Burnevich E, Niu JQ, Jung YJ, Jiang XJ, Xu M, Chen XY, Xie Q, Li J, Hou JL, Tang H, Dou XG, Gandhi Y, Hu WH, McPhee F, Noviello S, Treitel M, Mo L, Deng J. Daclatasvir plus asunaprevir in treatment-naïve patients with hepatitis C virus genotype 1b infection. World J Gastroenterol 2018; 24(12): 1361-1372
URL: https://www.wjgnet.com/1007-9327/full/v24/i12/1361.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i12.1361