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©The Author(s) 2018.
World J Gastroenterol. Mar 21, 2018; 24(11): 1250-1258
Published online Mar 21, 2018. doi: 10.3748/wjg.v24.i11.1250
Published online Mar 21, 2018. doi: 10.3748/wjg.v24.i11.1250
Table 3 Demographic and clinical characteristics of cirrhosis by hepatitis C virus infection in remunerated blood donors and multiple logistic regression analysis of factors associated with cirrhosis
Cirrhosis by HCV, n = 161 | CHC, n = 431 | P value | Multivariate4 | ||||
OR | 95%CI | Wald | P value | ||||
Age in yr | 58.4 ± 13.2 | 56.5 ± 9.4 | < 0.0011 | 2.143 | 0.553-6.453 | 4.543 | 0.002 |
≥ 40, < 50 | 41 (25.43) | 80 (18.6) | 0.0342 | 1 | |||
≥ 50, < 60 | 82 (50.9) | 270 (62.6) | 2.443 | 0.242-7.345 | 1.423 | 0.065 | |
≥ 60 | 38 (23.6) | 81 (18.8) | 3.223 | 0.124-14.344 | 3.153 | 0.021 | |
Sex | |||||||
Male | 75 (46.6) | 202 (46.9) | 0.9512 | 1 | |||
Female | 86 (53.4) | 229 (53.1) | 1.223 | 0.112-6.765 | 0.653 | 0.445 | |
Alcohol consumption | |||||||
Never | 97 (60.2) | 344 (79.8) | < 0.0012 | 1 | |||
Occasional | 40 (24.8) | 55 (12.8) | 0.879 | 0.647-2.654 | 2.753 | 0.152 | |
Often | 24 (14.9) | 32 (7.4) | 1.004 | 0.875-1.744 | 3.057 | 0.005 | |
BMI | 24.12 ± 2.32 | 25.45 ± 3.22 | 0.3531 | 0.647 | 0.465-1.632 | 4.135 | 0.432 |
< 25 | 78 (48.4) | 200 (46.4) | 0.1082 | 1 | |||
≥ 25, < 28 | 68 (42.2) | 162 (37.6) | 1.242 | 0.574-1.735 | 0.536 | 0.438 | |
≥ 28 | 15 (9.3) | 69 (16) | 0.665 | 0.426-1.645 | 0.476 | 0.537 | |
HOMA-IR | 1.53 ± 0.48 | 1.51 ± 0.52 | 0.556 | 0.023 | 0.772-1.423 | 0.365 | 0.221 |
PLT as × 109/L | 147.3 ± 55.7 | 176.3 ± 84.2 | < 0.0011 | 1.314 | 0.022-1.463 | 3.647 | 0.013 |
ALB in g/L | 42.3 ± 3.5 | 43.3 ± 4.5 | 0.5131 | 0.864 | 0.707-1.364 | 1.557 | 0.675 |
ALT in U/L | 67.4 ± 26.5 | 62.6 ± 25.4 | 0.1131 | 1.643 | 0.463-1.755 | 0.634 | 0.247 |
AST in U/L | 53.5 ± 27.4 | 54.5 ± 22.6 | 0.2011 | 1.425 | 0.428-1.254 | 0.546 | 0.664 |
SMA | |||||||
Negative | 144 (89.4) | 373 (86.5) | 0.3462 | 1 | |||
Positive | 17 (10.6) | 58 (13.5) | 0.526 | 0.537-1.843 | 1.034 | 0.536 | |
ANA | |||||||
Negative | 130 (80.7) | 347 (80.5) | 0.9451 | 1 | |||
Positive | 31 (19.3) | 84 (19.5) | 2.123 | 0.132-5.563 | 0.843 | 0.246 | |
IgG | |||||||
Normal | 60 (37.3) | 205 (47.6) | 0.0252 | 1 | |||
Elevated | 101 (62.7) | 226 (52.4) | 1.352 | 0.663-12.267 | 3.537 | 0.012 | |
HCV RNA in LgIU/mL | 7.12 ± 2.43 | 6.73 ± 2.533 | 0.0671 | 0.657 | 0.536-1.523 | 0.863 | 0.536 |
≥ 3, < 5 | 22 (13.7) | 51 (11.8) | 0.5462 | 1 | |||
≥ 5 | 139 (86.3) | 380 (88.2) | 1.325 | 0.972-1.445 | 0.143 | 0.782 | |
Genotype | |||||||
I | 152 (94.4) | 390 (90.5) | 0.3102 | 1 | |||
II | 8 (5.0) | 37 (8.6) | 0.753 | 1.003-1.664 | 0.623 | 0.242 | |
III | 1 (0.6) | 4 (0.9) | 1.862 | 1.182-1.635 | 0.845 | 0.118 | |
Blood donated frequency times | 8.67 ± 5.43 | 8.42 ± 6.25 | 0.1071 | 1.536 | 0.874-2.154 | 0.923 | 0.101 |
< 5 | 36 (22.4) | 103 (23.9) | 0.6982 | 1 | |||
< 10, ≥ 5 | 66 (41.0) | 186 (43.2) | 0.354 | 0.274-1.203 | 0.991 | 0.783 | |
≥ 10 | 59 (36.6) | 142 (32.9) | 1.024 | 0.154-2.163 | 0.332 | 0.224 | |
Refused donated by elevated ALT | |||||||
No | 94 (58.4) | 243 (56.4) | 0.6612 | 1 | |||
Yes | 67 (41.6) | 188 (43.6) | 0.012 | 0.037-1.002 | 0.682 | 0.563 |
- Citation: Tan YW, Tao Y, Liu LG, Ye Y, Zhou XB, Chen L, He C. Epidemiological features of chronic hepatitis C infection caused by remunerated blood donors: A nearly 27-year period survey. World J Gastroenterol 2018; 24(11): 1250-1258
- URL: https://www.wjgnet.com/1007-9327/full/v24/i11/1250.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i11.1250