Epidemiological features of chronic hepatitis C infection caused by remunerated blood donors: A nearly 27-year period survey

Table 2 Demographic and clinical characteristics of hepatitis C virus in remunerated blood donors and multiple logistic regression analysis of factors associated with hepatitis C virus

	CHC, n = 592	No CHC, n = 278	P value	Multivariate4
				OR	95%CI	Wald	P value
Age in yr	55.4 ± 13.2	58.5 ± 9.4	< 0.0011	1.642	0.426-11.164	3.012	0.013
≥ 40, < 50	121 (20.4)	35 (12.6)	0.0032	1
≥ 50, < 60	356 (60.1)	168 (60.4)		3.542	0.521-13.254	1.534	0.435
≥ 60	115 (19.4)	75 (27.0)		11.226	0.065-137.53	5.322	0.004
Sex
Male	277 (46.8)	111 (39.9)	0.0582	1
Female	315 (53.2)	167 (60.1)		0.233	0.054-6.634	1.004	0.364
Alcohol consumption				0.532	0.147-1.647	0.853	0.547
Never	441 (74.5)	175 (62.9)	0.0022	0.436	0.124-1.006	1.075	0.443
Occasional	95 (16.0)	68 (24.5)		0.876	0.857-1.354	1.446	0.374
Often	56 (9.5)	35 (12.6)		1.231	0.843-1.556	0.667	0.432
BMI	24.12 ± 2.32	25.45 ± 3.22	< 0.0011	0.889	0.674-1.327	0.896	0.547
< 25	278 (47.0)	194 (69.8)	< 0.0012	1.216	0.536-1.625	0.034	0.646
≥ 25, < 28	230 (38.9)	69 (24.8)		7.233	0.054-66.63	1.534	0.343
≥ 28	84 (14.2)	15 (5.4)		4.365	0.643-22.534	1.543	0.113
HOMA-IR	1.53 ± 0.48	1.31 ± 0.52	< 0.0011	1.002	0.864-1.007	0.984	0.657
PLT as × 109/L	164.3 ± 64.8	196.3 ± 73.1	< 0.0011	3.112	1.475-121.153	16.886	< 0.001
ALB in g/L	42.3 ± 3.5	43.3 ± 4.5	0.5131	0.576	0.645-1.2147	0.543	0.674
ALT in U/L	67.4 ± 26.5	22.6 ± 15.4	< 0.0011	3.216	1.036-121.625	25.034	< 0.001
AST in U/L	53.5 ± 17.4	24.5 ± 10.6	< 0.0011	2.578	0.937-76.354	26.332	< 0.001
SMA
Negative	517 (87.3)	262 (94.2)	0.0022	1
Positive	75 (12.7)	16 (5.8)		1.146	0.545-1.654	0.543	0.653
ANA
Negative	477 (80.6)	244 (87.8)	0.0092	1
Positive	115 (19.4)	34 (12.2)		1.423	0.587-1.001	0.123	0.886
IgG
Normal	271 (45.8)	261 (93.9)	< 0.0012	1
Elevated	321(54.2)	17 (6.1)		6.001	0.957-12.353	6.075	< 0.001
LSM in kPa	7.67 ± 4.43	4.12 ± 2.25	< 0.0011	0.233	0.054-6.634	1.004	0.364
< 6	155 (26.2)	241 (86.7)	< 0.0012	1
< 9, ≥ 6	211 (35.6)	31 (11.2)		0.532	0.147-1.647	0.853	0.547
≥ 9	226 (38.2)	6 (2.2)		2.436	0.124-11.776	7.075	< 0.001
Blood donated frequency times	8.67 ± 6.43	8.42 ± 6.25	0.1071	1.233	0.874-1.134	1.032	0.832
< 5	139 (23.5)	62 (22.3)	0.1012	1
< 10, ≥ 5	252 (42.6)	102 (36.7)		0.932	0.927-1.433	1.032	0.883
≥ 10	201 (34.0)	114 (41.0)		0.247	0.257-1.754	1.054	0.664
Refused donated by elevated ALT
No	377 (63.7)	148 (53.2)	0.0033	1
Yes	215 (36.3)	130 (46.8)		1.668	1.061-3.143	4.804	0.027

Data are presented as n (%). Alcohol consumption: Often, the ethanol intake per week was more than 140 g in men (70 g in women) in the past 12 mo; Occasional, the ethanol intake per week was less than 140 g in men (70 g in women) in the past 12 mo.

¹One-way analysis;

²Pearson’s chi-square;

³Fisher’s exact test;

⁴Binary logistic regression. ALB: Albumin; ALT: Alanine aminotransferase; ANA: Antinuclear antibody; AST: Aspartate aminotransferase; BMI: Body mass index; CI: Confidence interval; LSM: Liver stiffness measurement; OR: Odds ratio; SMA: Smooth muscle actin; PLT: Platelet.