Three-microRNA signature identified by bioinformatics analysis predicts prognosis of gastric cancer patients

Table 4 Univariate and multivariate Cox regression analyses of the association between the three differentially expressed miRNAs and clinical features

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age at diagnosis (≥ 60 vs < 60)	1.373 (0.948-1.988)	0.094	1.642 (1.122-2.401)	0.011a
Pathologic stage (III + IV vs I + II)	1.825 (1.332-2.499)	< 0.001a	1.252 (0.812-1.929)	0.309
T stage (T3 + T4 vs T1 + T2)	1.864 (1.197-2.902)	0.006a	1.623 (1.012-2.603)	0.044a
N stage (N1-2 vs N0)	2.005 (1.328-3.026)	0.001a	1.602 (0.935-2.744)	0.086
M stage (M1 vs M0)	1.368 (0.964-1.941)	0.080	1.313 (0.919-1.875)	0.134
Three-DEM signature (high vs low risk)	1.442 (1.018-1.988)	0.039a	1.451 (1.033-2.040)	0.032a

^aP < 0.05, statistically significant. DEMs: Differentially expressed miRNAs.