Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

Figure 5 Proteinase-activated receptor 2 knockdown inhibits tumor growth in nude mice. A and B: Subcutaneous xenografts of HepG2 and SMMC-7721 cells in nude mice growing for 4 wk; C and D: Tumor volumes were measured every week and tumor weights were tested at the end. ^bP < 0.01, ^eP < 0.001.