Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats

doi:10.3748/wjg.v24.i10.1093

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1093-1106
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1093

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Figure 8 Photomicrographs of pancreas. HC: Healthy control; DC: Disease control; MMF: Mycophenolate mofetil; MPA: Mycophenolic acid; MGLS: Prodrug of MPA and D-glucosamine; MGAS: Prodrug of MPA and D-galactosamine; GL: D-glucosamine; GA: D-galactosamine; GL + MPA: Physical mixture of D-glucosamine and MPA; GA + MPA oral: Physical mixture of D-galactosamine and MPA. DC group showing reduced number and size of islets of Langerhans while all other groups showed normal pancreas architecture without evidence of pancreatitis.

Citation: Chopade SS, Dhaneshwar SS. Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats. World J Gastroenterol 2018; 24(10): 1093-1106
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1093.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1093