Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells

Figure 6 Apoptotic effect of temperature and cisplatin in cancer cells. A: Early apoptosis was significantly induced by hyperthermia in cisplatin-treated cells, with the exception of Caco-2 cells, where temperature had no significant role. The dashed line represents control rates of apoptosis in untreated cells. Statistical analysis was performed using the Mann-Whitney U test. ^aP < 0.05. B: Dot plots presenting change of apoptosis in cisplatin untreated/treated cells and cultivated in hyperthermia. “-cis”: Cisplatin untreated cells; “+cis”: Cisplatin treated cells.