Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma

doi:10.3748/wjg.v24.i10.1152

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 14, 2018; 24(10): 1152-1166
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1152

Table 1 Prognostic significance of clinicopathological indicators, PGRMC1 and PGRMC2 for disease-free survival in the clinical cohort (n = 89)

Factor	DFS univariate				DFS multivariate
Factor	Group	HR	95%CI	P value	HR	95%CI	P value
Age, yr	< 60/≥ 60	0.997	0.609-1.632	0.989
Sex	Male/female	1.014	0.599-1.715	0.960
Viral infection				0.825
	B/C	1.177	0.703-1.971
	B/B + C	1.068	0.448-2.547
Child-Pugh score	5/≥ 6	2.407	1.346-4.302	0.003^a	2.005	(1.097-3.665)	0.024^a
Cirrhosis	-/+	0.743	0.664-1.776	0.299
Serum AFP	< 100/≥ 100 ng/ml	1.357	0.823-2.238	0.231
Differentiation	W/M-P	1.682	0.943-2.999	0.078
Multifocal tumor	-/+	0.985	0.514-1.888	0.965
Satellite nodule	-/+	2.173	1.303-3.624	0.003^a			NS
Tumor size	< 5/≥ 5 cm	2.446	1.486-4.028	< 0.001^a			NS
Tumor capsular invasion	-/+	0.985	0.545-1.780	0.959
Vascular invasion	-/+	2.551	1.553-4.190	< 0.001^a			NS
Liver capsule penetration	-/+	2.235	1.010-4.945	0.047^a			NS
Bile duct invasion	-/+	3.200	0.986-10.385	0.053
Margin status, mm	≥ 1 /< 1	3.793	2.079-6.920	< 0.001^a	4.720	(2.458-9.063)	< 0.001^a
AJCC stage	I-II/ IIIA-C	2.907	1.738-4.861	< 0.001^a	3.262	(1.895-5.617)	< 0.001^a
PGRMC1	H/L	1.918	1.145-3.213	0.013^a	2.384	(1.377-4.128)	0.002^a
PGRMC2	H/L	1.377	0.798-2.379	0.251
ER	-/+	0.528	0.128-2.173	0.376
PR	-/+	0.777	0.243-2.484	0.670

^aP < 0.05. DFS: Disease-free survival; AFP: Alpha-fetoprotein; AJCC: American Joint Committee on Cancer; H: High expression; L: Low expression.

Citation: Tsai HW, Ho CL, Cheng SW, Lin YJ, Chen CC, Cheng PN, Yen CJ, Chang TT, Chiang PM, Chan SH, Ho CH, Chen SH, Wang YW, Chow NH, Lin JC. Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma. World J Gastroenterol 2018; 24(10): 1152-1166
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1152.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1152