Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

doi:10.3748/wjg.v24.i10.1120

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1120-1133
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1120

Table 3 Multivariate analysis of the association of prognosis with clinicopathological variables and proteinase-activated receptor 2 expression in hepatocellular carcinoma patients

Clinicopathological variable	Hazard ratio	P value
Gender (male vs female)	0.214	0.672
Age (< 60 vs ≥ 60)	0.126	0.763
TNM stage (I-II III-IV)	4.292	0.016^a
Tumor size (≤ 5 cm vs >5 cm)	2.193	0.034^a
Microvascular invasion (present vs absent)	2.499	0.029^a
HBsAg (negative vs positive)	1.072	0.092
Serum AFP level (< 400 ng/mL vs ≥ 400 ng/mL)	3.688	0.023^a
PAR2 expression (high vs low)	1.814	0.041^a

^aP < 0.05. HBsAg: Hepatitis B surface antigen; AFP: Alpha-fetoprotein; PAR2: Proteinase-activated receptor 2.

Citation: Sun L, Li PB, Yao YF, Xiu AY, Peng Z, Bai YH, Gao YJ. Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. World J Gastroenterol 2018; 24(10): 1120-1133
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1120.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1120