Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats

doi:10.3748/wjg.v24.i10.1093

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 24, Issue 10

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6980)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-9) series, Tables (1-3) series.

Item

Count

PDF

343

WORD

175

HTML

4032

Figures (1-9)

267

Tables (1-3)

256

Sum=5073

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

762

Download

1145

Sum=1907

Mar 14, 2018 (publication date) through Nov 8, 2024

Times Cited of This Article

Times Cited (7)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Mar 14, 2018; 24(10): 1093-1106
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1093

Table 2 Results of in vitro release in different incubation media

Prodrug	Incubation media
	Aqueous buffers pH 1.2 and pH 7.4	Stomach and intestinal homogenates	Colon homogenate				Faecal matter
	Aqueous buffers pH 1.2 and pH 7.4	Stomach and intestinal homogenates	K ± SD (min^-1)¹	t_1/2 (min)	% Prodrug hydrolysed	% MPA released	% Prodrug hydrolysed	% MPA released
MGLS	Stable	1.30%	0.0025 ± 0.000978	275	92.6	86.7	63	54
MGAS	Stable	14-19%	0.000108 ± 0.00001	305	79.15	76.4	47	52

¹Average of six readings, follows first-order kinetics. MGLS: Prodrug of mycophenolic acid and D-glucosamine; MGAS: Prodrug of mycophenolic acid and D-galactosamine.

Citation: Chopade SS, Dhaneshwar SS. Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats. World J Gastroenterol 2018; 24(10): 1093-1106
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1093.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1093