Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats

doi:10.3748/wjg.v24.i10.1093

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1093-1106
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1093

Table 1 Doses of test and standard compounds

Groups	Dose¹ (mg/kg)
HC	0.9% saline (1 mL)
MPA	18.5
MMF	25.0
MGLS	28.5
MGAS	28.5
D- Glucosamine	12.4
D- Galactosamine	12.4
MPA + GL	18.5 + 12.4
MPA + GA	18.5 + 12.4

¹All doses were calculated on an equimolar basis to the dose of MPA. HC: Healthy control; MPA: Mycophenolic acid; MMF: Mycophenolate mofetil; MGLS: Prodrug of MPA and D-glucosamine; MGAS: Prodrug of MPA and D-galactosamine; MPA + GL: Physical mixture of MPA and D-glucosamine; MPA + GA: Physical mixture of MPA and D-galactosamine.

Citation: Chopade SS, Dhaneshwar SS. Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats. World J Gastroenterol 2018; 24(10): 1093-1106
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1093.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1093