Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome

Figure 2 Immunohistochemical staining for leptin and leptin receptor in irritable bowel syndrome patients and healthy controls. A: Colonic mucosal leptin expression in IBS-D patients (× 400); B: Colonic mucosal leptin expression in healthy controls (× 400); C: Colonic mucosal leptin receptor expression in IBS-D patients (× 400); D: Colonic mucosal leptin receptor expression in healthy controls (× 400); E: Colonic mucosal leptin immunoreactivity significantly increased in IBS-D patients than in the healthy controls; F: Colonic mucosal leptin receptor immunoreactivity did not increase significantly in IBS-D patients than in healthy controls. Line in the scatter plots means the median. IBS-D: Iirritable bowel syndrome with diarrhea; IOD: Integral optical density.