Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas

Table 4 Univariate analysis results: Disease-free, overall and disease-specific survival after hepatic resection for hepatocellular carcinoma (hepatitis B virus, n = 68)

		DFS		OS		DSS
Characteristics	n	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age			0.9417		0.8991		0.3769
≤ 67	54	1		1		1
> 67	14	0.97131 (0.445, 2.1202)		1.05615 (0.4541, 2.4565)		0.5123 (0.1162, 2.2588)
Gender			0.6063		0.1844		0.3363
Female	9	1		1		1
Male	59	1.28118 (0.4993, 3.2876)		2.64152 (0.6294, 11.0865)		2.70202 (0.3562, 20.4981)
Smoking habit (Ex + current)			0.8323		0.5660		0.9544
Absent	21	1		1		1
Present	47	0.93056 (0.478, 1.8115)		1.26612 (0.5656, 2.8343)		0.96953 (0.336, 2.7975)
Smoking habit (current)			0.4008		0.3620		0.8001
Absent	36	1		1		1
Present	32	1.30547 (0.7009, 2.4314)		1.38988 (0.6848, 2.8209)		1.13501 (0.4258, 3.0251)
Alcohol abuse			0.0183		0.0706		0.5674
Absent	46	1		1		1
Present	22	0.4139 (0.199, 0.861)		0.45823 (0.1966, 1.0679)		0.73339 (0.2534, 2.1228)
Diabetes mellitus			0.4682		0.6700		0.8752
Absent	56	1		1		1
Present	12	1.32065 (0.6229, 2.7999)		1.21513 (0.4959, 2.9773)		1.10618 (0.3141, 3.8962)
BMI			0.3087		0.9126		0.6383
≤ Median	33	1		1		1
> Median	35	1.3863 (0.7392, 2.6)		0.96125 (0.4746, 1.9468)		1.26746 (0.4718, 3.4046)
ICG R15 (%)			0.6240		0.8562		0.5468
≤ Median	49	1		1		1
> Median	19	0.83516 (0.4064, 1.7163)		1.07744 (0.4808, 2.4147)		1.38526 (0.4799, 3.9983)
AFP			0.0665		0.0015		0.0114
≤ Median	34	1		1		1
> Median	34	1.80218 (0.9606, 3.3809)		3.54578 (1.6235, 7.7443)		4.36412 (1.3942, 13.6606)
Tumor size			0.1252		0.2124		0.0585
≤ Median	28	1		1		1
> Median	40	1.67393 (0.8665, 3.2339)		1.61822 (0.7594, 3.4483)		3.37156 (0.9574, 11.8735)
Solitary/Multiple			0.0002		0.0001		0.0013
Solitary	41	1		1		1
Multiple	27	3.30417 (1.7552, 6.2201)		4.6829 (2.1913, 10.0073)		6.42975 (2.0644, 20.0257)
Vp			0.0598		0.0035		0.0362
Absent	39	1		1		1
Present	29	1.85208 (0.975, 3.5182)		2.94188 (1.4258, 6.07)		2.92487 (1.0717, 7.9823)
T12/T34			0.0042		0.0001		0.0019
T12	32	1		1		1
T34	36	2.60213 (1.3531, 5.0043)		5.55785 (2.3542, 13.1211)		10.58522 (2.3795, 47.0876)

DFS: Disease-free survival; OS: Overall survival; DSS: Disease-specific survival.