Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas

Table 2 Univariate analysis results: Disease-free, overall and disease-specific survival after hepatic resection for hepatocellular carcinoma (hepatitis C virus, n = 273)

		DFS		OS		DSS
Characteristics	n	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age			0.9234		0.5143		0.7101
≤ 67	133	1		1		1
> 67	140	1.01381 (0.7665, 1.3409)		1.10679 (0.8159, 1.5015)		0.92155 (0.599, 1.4177)
Gender			0.5699		0.5110		0.2434
Female	70	1		1		1
Male	203	0.91269 (0.666, 1.2508)		1.12916 (0.786, 1.6221)		1.38366 (0.8019, 2.3876)
Smoking habit (Ex + current)			0.5978		0.1262		0.2147
Absent	111	1		1		1
Present	162	0.92696 (0.6994, 1.2286)		1.27849 (0.9332, 1.7516)		1.32797 (0.8483, 2.0788)
Smoking habit (current)			0.8864		0.0144		0.0483
Absent	185	1		1		1
Present	88	1.02258 (0.7527, 1.3892)		1.47783 (1.0808, 2.0207)		1.55795 (1.0033, 2.4192)
Alcohol abuse			0.0321		0.8232		0.7027
Absent	210	1		1		1
Present	63	0.68132 (0.4797, 0.9678)		0.95952 (0.6677, 1.3788)		0.90325 (0.5356, 1.5232)
Diabetes mellitus			0.3149		0.5259		0.9487
Absent	211	1		1		1
Present	62	1.18657 (0.85, 1.6564)		1.12207 (0.7861, 1.6017)		0.98302 (0.5831, 1.6572)
BMI			0.0270		0.2082		0.6409
≤ Median	137	1		1		1
> Median	136	0.72863 (0.5503, 0.9647)		0.82193 (0.6056, 1.1155)		0.9026 (0.5868, 1.3884)
ICG R15 (%)			0.0088		0.2391		0.6896
≤ Median	111	1		1		1
> Median	162	1.47199 (1.1021, 1.9659)		1.20672 (0.8825, 1.65)		1.09334 (0.7056, 1.6941)
AFP			0.2274		0.0402		0.1371
≤ Median	136	1		1		1
> Median	137	1.18795 (0.8981, 1.5713)		1.37689 (1.0144, 1.8689)		1.38776 (0.901, 2.1376)
Tumor size			0.0305		0.0019		0.0070
≤ Median	161	1		1		1
> Median	112	1.37235 (1.0303, 1.828)		1.63014 (1.1982, 2.2178)		1.81608 (1.1773, 2.8016)
Solitary/Multiple			0.0021		0.0001		0.1182
Solitary	182	1		1		1
Multiple	91	1.59365 (1.1835, 2.1459)		1.8536 (1.3563, 2.5332)		1.43932 (0.9115, 2.2728)
Vp			0.0767		0.0004		0.0177
Absent	199	1		1		1
Present	74	1.33528 (0.9695, 1.839)		1.81728 (1.3073, 2.5262)		1.76737 (1.104, 2.8294)
T12/T34			< 0.0001		0.0008		0.0315
T12	156	1		1		1
T34	117	1.81021 (1.3644, 2.4017)		1.68381 (1.2412, 2.2843)		1.60589 (1.0429, 2.4728)

DFS: Disease-free survival; OS: Overall survival; DSS: Disease-specific survival.