Meta-Analysis
Copyright ©The Author(s) 2018.
World J Gastroenterol. Jan 7, 2018; 24(1): 139-149
Published online Jan 7, 2018. doi: 10.3748/wjg.v24.i1.139
Table 1 Main characteristics of the studies included in the quantitative analysis
Ref.NationAge and sexProbiotic strain and doseDiagnosisControl of eradicationEradication rate % (n/N)
Boonyaritichaikij et al[27], 2009Japan62 ± 14 yrCheese with L. gasseri OLL2716 5 × 108 CFU/g for 12 moSATSAT after 12 moProbiotic: 29.3% (24/82)
Male sex: 54.5%Placebo: 0% (0/6)
Dore et al[28], 2014ItalyMean age: 51 yr (range, 21-68)L. reuteri 108 CFU/tablet bid + Pantoprazole 20 mg bid for 60 dUBTUBT after 30-40 d14.3% (3/21)
Male sex: 13.6%
Francavilla et al[29], 2008Italy53.3 ± 13.3 yr (probiotics)L. reuteri ATCC55730 108 CFU/tablet bid for 28 dUBT (cut-off 3.5%), SAT, RUT, histologyUBT after 4 wkProbiotic: 0% (0/20)
52.4 ± 13.1 yr (placebo)Placebo: 0% (0/20)
Male sex: 57.5%
Gotteland et al[30], 2005Chile8.5 ± 1.7L. acidophilus LB 109/tablet bid or S. boulardii 250 mg + inulin 5 g bid for 8 wkUBT (cut-off 5‰)UBT after 1 d9.3% (9/97)
Male sex: 49.6%L. acidophilus 6.5% (3/46)
S. boulardii 11.8% (6/51)
Myllyluoma et al[31], 2007FinlandMean age: 51 yr (range, 40-69)Multi-strain (L. rhamnosus GG, L. rhamnosus LC705, P. freudenreichii JS, B. lactis Bb12) 2.5 × 109 CFU/day for 8 wkUBT (cut-off 2.2%), RUT, histologyUBT after 8 wk0% (0/6)
Pantoflickova et al[32], 2003Switzerland25 ± 5 yrL. johnsonii bid for 3 wk, then once daily for 13 wkUBT (cutoff 5%), histology, culture, RUT, serologyUBT, culture at the end of treatmentProbiotic: 0% (0/25)
Male sex: 50%Placebo: 0% (0/25)
Rosania et al[33], 2012Italy52.4 ± 21.7 yr (probiotics)Multi-strain (S. termophilus, L. acidophilus, B. longum, L. plantarum, B. brevis, L. paracasei, B. infantis, L. delbrueckii) 1800 × 109/d for 10 dUBT (cut-off 4%)UBT after 4 wkProbiotic: 32.5% (13/40)
48.7 ± 25.3 yr (placebo)Placebo: 0% (0/40)
Male sex: 42.5%
Sakamoto et al[34], 2001Japan50.1 ± 7.4 yrYoghurt + L. gasseri OLL2716 1-1.4 × 107 CFU/g bid for 8 wkUBT (cut-off 5%)UBT after 9 wk0% (0/29)
Male sex: 93.1%
Shimizu et al[35], 2002JapanMean age: 12.1 yr (range, 7.4-15.8) Male sex: 41.7%Yoghurt + L. gasseri OLL2716 1-1.4 × 107 CFU/g bid for 8 wkSAT, UBTSAT, UBT after 4 and 10 wk0% (0/12)
Wang et al[36], 2004ChinaNot availableMulti-strain yoghurt (L. acidophilus La5, B. lactis Bb12, L. bulgaricus, S. termophilus) > 107 bacteria/mL for 6 wkUBT (cut-off 3.5%), histologyUBT after 8 wkProbiotic: 1.7% (1/59)
Placebo: 0% (0/11)
Namkin et al[37], 2016IranAge range of 9-12 yrS. boulardii 250 mg/d for 1 moSATSAT after 8 wkProbiotic: 0% (0/12)
Male sex: 20.8%Placebo: 0% (0/12)