Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

Figure 2 Detection of iodine concentration value in a 50-year-old man with moderate differentiated adenocarcinoma, of staging IIIa (T4aN1M0). A: Monochromatic image shows focal wall thickening in the gastric cardia and lesser curvature; B: The iodine-water image with iodine concentration (IC) value 11.78 (100 µg/cm³), normalized IC (nIC) value 0.09 in the arterial phase; Monochromatic image (C) and (D) iodine-water image with IC value 18.63 (100 µg/cm³), nIC value 0.34 in the venous phase; E: Hematoxylin and eosin staining shows a moderately differentiated, intestinal Lauren subtype (× 400); F: Immunohistochemical staining shows CD34 positive micro-vessel (micro-vessel density count: 27/magnification × 400); G: Strongly positive vascular endothelial growth factor staining (× 400) with score 5.