Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

Figure 1 Detection of the iodine concentration value in a 51-year-old man with poorly differentiated adenocarcinoma, with staging IIIc (T4aN3M0). A: The monochromatic image shows focal wall thickening in the gastric antrum; B: The iodine-water image with iodine concentration (IC) value 12.83 (100 µg/cm³), normalized IC (nIC) value 0.11 in the arterial phase. Monochromatic image (C) and iodine-water image (D) with IC value 23.91 (100 µg/cm³), nIC value 0.53 in the venous phase; E: Hematoxylin and eosin staining of a pathological section obtained from radical surgery shows poorly differentiated, diffused subtype in the Lauren classification (× 400); F: CD34-staining shows endothelial cells stained brown; micro-vessels form clusters or have tiny hollow lumens (micro-vessel density 45/magnification × 400). G: Weak vascular endothelial growth factor staining in the cytoplasm (× 400) with score 2.