Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

Table 3 Correlations between bi-phase normalized iodine concentration and microvessel density in different clinical-pathological subgroups

Varieties	n	nIC-AP vs MVD		nIC-VP vs MVD
		r	P value	r	P value
Depth of invasion
< T4	7	0.851	0.015a	0.600	0.154
T4	27	0.370	0.057	0.656	0.000a
Nodal status
N0	11	0.620	0.042a	0.600	0.051
N1-3	23	0.330	0.124	0.644	0.001a
Histologic differentiation
Highly and Moderately differentiated	17	0.250	0.334	0.190	0.466
Poorly differentiated	17	0.427	0.087	0.799	0.000a
Lauren subtype
Intestinal type	15	0.222	0.427	0.101	0.719
Mixed type	7	0.741	0.057a	0.827	0.022a
Diffuse type	12	0.145	0.653	0.765	0.004a
Tumor location
Cardia/Fundus	14	0.311	0.279	0.760	0.796
Gastricum	9	0.385	0.307	0.507	0.163
Antrum	11	0.616	0.044a	0.891	0.000a
Sex
Male	23	0.385	0.070	0.606	0.002a
Female	11	0.696	0.017a	0.605	0.049

^aP < 0.05. nIC-AP: Normalized iodine concentration in arterial phase; nIC-VP: Normalized iodine concentration in venous phase; MVD: Microvessel density.