Current knowledge on the laboratory diagnosis of Clostridium difficile infection

Table 2 Sensitivity and specificity of nucleic acid amplification test assays for the detection of Clostridium difficile

Assay	Sensitivity	Specificity	Ref.
Cepheid Xpert C. difficile	90%-100%	92.9%-98.6%	[87,89,91]
IMDx C. difficile for Abbott m2000 Assay	62.1%-92.8%	99.4%-100%	[92,93]
BD Max Cdiff Assay	81.6%-96.9%	95%-95.8%	[92,93]
Portrait Toxigenic C. difficile Assay	98.2%	92.8%	[95]
Quidel Lyra Direct C. difficile Assay	82.1%-85.7%	96.9%-98.3%	[96]
Verigene C. difficile nucleic acid test	95.2%-98.7%	87.5%-99.4%	[97,128]
Simplexa C. difficile Universal Direct real time PCR	87%-98%	100%	[99,128]
AmpliVue C. difficile assay	91%-96%	89%-100%	[99,100]
Illumigene C. difficile assay	93.3%-100%	95.1%-100%	[95,101]
BD GeneOhm Cdiff assay	89.6%-97.4%	96.7%-98.5%	[95,103]
ProGastro Cd assay	77.93%-100%	93.4%-99.2%	[103,104]

C. difficile: Clostridium difficile.