Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis

Figure 2 Effect of different dosages of Da-Cheng-Qi decoction on inflammatory mediators in liver tissues from rats with severe acute pancreatitis. Rats (n = 6 per group) were orally administered with different doses of Da-Cheng-Qi decoction (DCQD) (6 g/kg for the LDG, 12 g/kg for the MDG, and 24 g/kg for the HDG) 2 h after operation. After 24 h, the livers were collected to examine pro-inflammatory cytokine (IL-6 and TNF-α) and anti-inflammatory cytokine (IL-4 and IL-10) levels. The inflammatory cytokines were measured by ELISA. The results are represented as the mean ± SD. ^aP < 0.05 vs SOG and ^bP < 0.05 vs MG. SOG: Sham operation group; MG: Model group; LDG: Low-dose group; MDG: Medium-dose group; HDG: High-dose group.