TGR5 expression in benign, preneoplastic and neoplastic lesions of Barrett’s esophagus: Case series and findings

Figure 1 TGR5 mRNA levels in different cell lines. A: TGR5 mRNA level was significantly higher in Barrett’s cell line CP-A than in squamous cell line HET-1A; B: Levels of TGR5 mRNA were significantly increased in Barrett’s dysplastic cell line CP-D and EA cell line SK-GT-4, when compared with CP-A cells. In addition, TGR5 mRNA was significantly higher in SK-GT-4 cells than in CP-D cells. These data suggest that TGR5 may play an important role in the progression from BE to EA. n = 3, t test, ^aP < 0.02; ANOVA, ^bP < 0.01 vs CP-A.